|
|
International Journal of Molecular and Cellular Medicine، جلد ۵، شماره ۳، صفحات ۱۶۰-۱۶۶
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Utility of Specific IgE to Ara h 2 in Italian Allergic and Tolerant Children Sensitized to Peanut |
|
| چکیده انگلیسی مقاله |
Emerging data suggest that measurement of serum IgE to peanut components can be clinically helpful and more accurate than IgE to whole peanut to predict peanut allergy. Not all studies have used prospective samples, multiple components and oral challenges. Currently, there are no data on this topic involving Italian children. 32 patients (23 males; median age 9 years) with reported history for peanut allergy and evidence of peanut sensitization (skin prick test to peanut extract ≥ 3mm) have been analyzed for serum IgE to whole peanut and recombinant allergen components Ara h 1, 2, 3, 8, and 9 with Immuno CAP and completed an open oral food challenge with peanut. 12 (37.5%) children had a positive challenge to peanut and were considered allergic. No differences were seen between the median values of IgE to peanut, Ara h 1, 3, 8 and 9 in allergic and tolerant children to peanut challenge. Noteworthy, 5 of 20 tolerant children had IgE to peanut> 15 kUA/l which is commonly considered a predictive value of peanut allergy. Conversely, a significant difference was seen when comparing the median value of IgE to Ara h 2 in the two groups: 0.75 kUA/l (IQR: 0.22-4.34 kUA/l) in allergic children versus 0.1 kUA/l (IQR: 0.1-0.12 kUA/l) in tolerant ones (P< 0.001). IgE levels to Ara h 2 are significantly higher in children that react to oral peanut challenge. Our findings in Italian children have been in line with recent reports in various populations of Northern Europe, the US and Australia and add confirmatory evidence that analysis of IgE to Ara h 2 could reduce the need for peanut challenge in suspected allergic patients. |
|
| کلیدواژه‌های انگلیسی مقاله |
Allergy, Ara h 2, peanut, specific Ig E |
|
| نویسندگان مقاله |
pasquale comberiati | pasquale comberiati
department of scienze chirurgiche, odontostomatologiche e materno-infantili, section of paediatrics, university of verona, italy.
لورا colavita | laura colavita
department of paediatrics, unit of genetics and pediatric immunology, university hospital of messina, italy.
federica minniti | federica minniti
department of scienze chirurgiche, odontostomatologiche e materno-infantili, section of paediatrics, university of verona, italy.
paiola giulia | paiola giulia
department of scienze chirurgiche, odontostomatologiche e materno-infantili, section of paediatrics, university of verona, italy.
carlo capristo | carlo capristo
department of paediatrics, faculty of medicine, second university of naples, naples, italy.
cristoforo incorvaia | cristoforo incorvaia
allergy pulmonary rehabilitation, icp hospital, milan, italy.
giampietro peroni diego | giampietro peroni diego
department of clinical and experimental medicine, section of paediatrics, university of pisa, italy.
|
|
| نشانی اینترنتی |
http://www.ijmcmed.org/browse.php?a_code=A-10-762-1&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
1 |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|