| چکیده انگلیسی مقاله |
Metabolic syndrome (MetS) is characterized by a cluster of cardiovascular risk factors that include: abdominal obesity, dyslipidaemia, hypertension, insulin resistance and impaired glucose tolerance. Recent genome wide association studies have identified several susceptibility regions involved in lipid metabolism that are also associated with MetS. We have explored the association of 9 genetic polymorphisms involved in lipid metabolism and hypertension, including: MTHFR C677T, SELE L554F, FGB - 455G>A, GNB3 C825T, ZNF259 C>G, PSRC-1 A>G, CETP I405V, LPL S447X and LPA C>T in 97 subjects with mets and 96 individuals without MetS who were recruited randomly from Mashhad stroke and heart atherosclerotic disorder (MASHAD) study using a stratified cluster random sampling technique. Anthropometric parameters and biochemical measurements were determined in all the subjects. Genotyping was carried out followed by univariate and multivariate analyses. The subjects with MetS had a higher triglyceride and lower HDL- C. CG+ GG genotypes of ZNF259 polymorphism (rs964184 C>G) and TT+CT genotypes of MTHFR C677T (rs1801133) were associated with MetS, and individuals carrying the G allele for ZNF259 or the T allele for MTHFR polymorphisms were associated with MetS (e.g, odds ratio (OR) for CG+GG genotypes vs. CC wild type: 2.52, CI=1.33-4.77; P=0.005). However, after multiple comparison adsustments, this relationship remained significant only for CG+ GG genotypes of ZNF259 polymorphism. Moreover, the ZNF259 CG+ GG genotypes were associated with increased serum concentrations of triglycerides and LDL-C, compared to the wild type. These data support the necessity of further studies in larger multicenter settings. |
| نویسندگان مقاله |
سید رضا میرحافظ | seyed reza mirhafez
department of basic medical sciences, neyshabur university of medical sciences, neyshabur, iran.
امیر آوان | amir avan
department of modern science and technologies; and biochemistry of nutrition research center; school of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
علیرضا پاسدار | alireza pasdar
division of applied medicine, medical school, university of aberdeen, foresterhill, aberdeen, ab25 2zd, uk.
سارا khatamianfar | sara khatamianfar
department of modern science and technologies; and biochemistry of nutrition research center; school of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
لیلا حسین زاده | leila hosseinzadeh
department of modern science and technologies; and biochemistry of nutrition research center; school of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
شیوا گنجعلی | shiva ganjali
department of modern science and technologies; and biochemistry of nutrition research center; school of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
علی موحدی | ali movahedi
department of basic medical sciences, neyshabur university of medical sciences, neyshabur, iran.
مریم پیرهوشیاران | maryam pirhoushiaran
vu university medical center, amsterdam, de boelelaan 1117, 1081 hv amsterdam, the netherlands.
valentina گومز mellado | valentina gómez mellado
vu university medical center, amsterdam, de boelelaan 1117, 1081 hv amsterdam, the netherlands.
domenico rosace | domenico rosace
university of bologna, bologna, italy.
anne وان krieken | anne van krieken
peter maccallum centre, st andrew apos;s place, melbourne, australia.
مهدی نهتانی | mahdi nohtani
department of modern science and technologies; and biochemistry of nutrition research center; school of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
گوردون a ferns | gordon a ferns
brighton amp; sussex medical school, division of medical education, falmer, brighton, sussex bn1 9ph, uk.
مجید غیور مبرهن | majid ghayour mobarhan
department of modern science and technologies; and biochemistry of nutrition research center; school of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
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