International Journal of Molecular and Cellular Medicine، جلد ۵، شماره ۱، صفحات ۴۹-۵۶
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عنوان انگلیسی Orosomucoid-1 Expression in Ameloblastoma Variants
چکیده انگلیسی مقاله Odontogenic tumors constitute a group of heterogeneous lesions of benign and malignant neoplasms with variable aggressiveness. Ameloblastomas are a group of benign but locally invasive neoplasms that occur in the jaws and are derived from epithelial elements of the tooth-forming apparatus. We previously described orosomucoid-1 protein expression in odontogenic myxomas. However, whether orosomucoid-1 is expressed in other odontogenic tumors remains unknown. Since orosomucoid-1 belongs to a group of acute-phase proteins and has many functions in health and disease, we identified and analyzed orosomucoid-1 expression in ameloblastoma variants and ameloblastic carcinoma using western blot and immunohistochemical techniques. Thirty cases of ameloblastoma were analyzed for orsomucoid-1; five specimens were fresh for western blot study (four benign ameloblastomas and one ameloblastic carcinoma), and 25 cases of benign ameloblastoma for immunohistochemical assays. Orosomucoid-1 was widely expressed in each tumor variant analyzed in this study, and differential orosomucoid-1 expression was observed between benign and malignant tumor. Orosomucoid-1 may play an important role in the behavior of ameloblastomas and influence the biology and development of the variants of this tumor.
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نویسندگان مقاله alejandro گارسیا muñoz | alejandro garcía muñoz
laboratorio de investigación en odontología, almaraz ubimed, fes iztacala, unam. state of mexico, mexico.


ronell bologna molina | ronell bologna molina
molecular pathology, universidad de la república udelar , montevideo, uruguay.


mario a رودریگویز | mario a rodríguez
department of infectomics and molecular pathogenesis, cinvestav-ipn, méxico, d.f, méxico.


رودریگو liceaga reyes | rodrigo liceaga reyes
maxillofacial surgery department. hospital juárez de méxico, méxico d.f, méxico.


خوزه eduardo farfán morales | jose eduardo farfán morales
instituto nacional de pediatría, méxico d.f, méxico.


سرای aranda romo | saray aranda romo
biochemistry, microbiology and pathology laboratory, faculty of stomatology, universidad autónoma de san luis potosí, san luis potosí, mexico.


nelly molina frechero | nelly molina frechero
health care department, universidad autónoma metropolitana, xochimilco, uam, méxico city, mexico.


rogelio gonzález gonzález | rogelio gonzález gonzález
department research, school of dentistry, universidad juárez del estado de durango, méxico.
نشانی اینترنتی http://www.ijmcmed.org/browse.php?a_code=A-10-626-1&slc_lang=en&sid=en
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نوع مقاله منتشر شده 6
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