| چکیده انگلیسی مقاله |
The biological interaction between the jaw bones and dental implant is fundamental for the long-term success of dental implant placement. Nevertheless, the insufficient bone volume remains a major clinical problem, especially in case of immediate dental implant. Using a canine model, the present study proves the regenerative potential of adipose- derived stem cells (ADSCs) to repair peri-implant bone defects occurring in immediate dental implant placement. In six labradors, all mandibular premolars and the first molars were extracted bilaterally and three months later dental implants were installed with a marginal gap. The marginal defects were filled with hydroxyapatite (HA)-based scaffolds previously seeded with ADSCs. After one month of healing, specimens were prepared for histological and histomorphometric evaluations. Histological analyses of ground sections show that ADSCs significantly increase bone regeneration. Several new vessels, osteoblasts and new bone matrix were detected. By contrast, no inflammatory cells have been revealed. ADSCs could be used to accelerate bone healing in peri- implant defects in case of immediate dental implant placement. |
| نویسندگان مقاله |
eriberto bressan | eriberto bressan
department of neurosciences, university of padua, padua, italy.
daniele botticelli | daniele botticelli
faculty of dentistry, university of medical science, la habana, cuba.
stefano sivolella | stefano sivolella
department of neurosciences, university of padua, padua, italy.
فرانکو bengazi | franco bengazi
faculty of dentistry, university of medical science, la habana, cuba.
riccardo guazzo | riccardo guazzo
department of neurosciences, university of padua, padua, italy.
luca sbricoli | luca sbricoli
department of neurosciences, university of padua, padua, italy.
سارا ricci | sara ricci
department of neurosciences, university of padua, padua, italy.
letizia ferroni | letizia ferroni
department of biomedical sciences, university of padua, via bassi 58, 35100 padua, italy.
chiara gardin | chiara gardin
department of biomedical sciences, university of padua, via bassi 58, 35100 padua, italy.
joaquin urbizo velez | joaquin urbizo velez
faculty of dentistry, university of medical science, la habana, cuba.
باربارا zavan | barbara zavan
department of biomedical sciences, university of padua, via bassi 58, 35100 padua, italy.
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