| چکیده انگلیسی مقاله |
The effects of chronic stress and glucocorticoids receptor antagonist (RU486) on expression of melanocortin 4 receptor (MC4R) mRNA in arcuate nucleus (ARC) of male rats were evaluated. In this study, adult male Sprague Dawley rats were placed into four groups (n=6/group) stress, RU486, stress/RU486, and control groups. In stress group, the rats were restrained, 1 h/day, for 12 days. In RU486 group, the rats were injected RU486 for 12 days. In stress/RU486 group, the rats were injected RU486 1 h before the stress process for 12 days. Relative expression of MC4R mRNA was determined using real-time PCR. Relative expression of MC4R mRNA in the stress group was higher than that of the control rats (P< 0.05). Relative expressions of MC4R mRNA were not different between the stress, RU486 and stress/RU486 groups (P>0.05). Chronic restraint stress causes increase in mRNA expression of MC4R in ARC and blockade of glucocorticoid receptors has no effect on this up-regulation. |
| نویسندگان مقاله |
مریم کرمی خیرآباد | maryam karami kheirabad
department of basic sciences, azad university, gachsaran branch, gachsaran, iran.
بهیه نام آور جهرمی | bahia namavar jahromi
infertility research center, department of ob-gyn, school of medicine, shiraz university of medical sciences, shiraz, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
امین تمدن | amin tamadon
transgenic technology research center, shiraz university of medical sciences, shiraz, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
امین رمضانی | amin ramezani
department of medical biotechnology, school of advanced medical sciences and technology, shiraz university of medical sciences, shiraz, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
سازمان های دیگر: Institute of Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran.
سمیه احمدلو | somayeh ahmadloo
infertility research center, department of ob-gyn, school of medicine, shiraz university of medical sciences, shiraz, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
فاطمه ثابت سروستانی | fatemeh sabet sarvestani
infertility research center, department of ob-gyn, school of medicine, shiraz university of medical sciences, shiraz, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
امید کوهی حسین آبادی | omid koohi hosseinabadi
laboratory animal center, shiraz university of medical sciences, shiraz, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
|