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International Journal of Molecular and Cellular Medicine، جلد ۴، شماره ۲، صفحات ۱۲۰-۱۲۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Multiple Inherited Thrombophilic Gene Polymorphisms in Spontaneous Abortions in Turkish Population |
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| چکیده انگلیسی مقاله |
The aim of this study was to investigate the possible role of multiple inherited thrombophilic gene variations in women with unexplained spontaneous abortions. For this purpose, the Factor V Leiden (FVL) (rs6025), Prothrombin G20210A (rs1799963), MTHFR C677T (rs1801133), PAI-1 4G/5G (rs1799889), ACE I/D (rs1799752), eNOS E298D (rs1799983), and Apo E E2/E3/E4 (rs429358) polymorphisms were genotyped and correlated in spontaneously aborted fetal materials, their mothers and fertile women. Twenty three abortion materials, 22 women with ≥1 unexplained fetal loss, and 22 control subjects with at least two healthy term infants as a control group were studied. Target SNPs for each gene were analyzed by real time-PCR technique after genomic DNA isolation from maternal blood-EDTA, control group blood-EDTA and spontaneously aborted fetal tissues. Some cases had a single thrombophilic polymorphism, but the rest of the patients and fetal materials had combined thrombophilic polymorphisms. The PAI-1 4G/5G+4G/4G (P= 0.0017), 4G/4G (P= 0.0253), eNOS 894GT+894TT (P=0.0011) genotypes and T allele (P=0.0185), Apo E E3/E4+E3/E2+E2/E4 (P< 0.0001) genotypes, E2 (P< 0.0001) and E4 (P< 0.0001) alleles were higher in spontaneously aborted fetal materials when compared to their mothers and control group. The Factor V Leiden rs6025, Prothrombin G20210A, MTHFR C677T, ACE I/D genotypes were different for each group but not statistically significant due to relatively small size of the samples (P>0.05). Our results indicated that combined thrombophilic gene variations may be associated with increased risk for spontaneous abortions and results need to be confirmed by larger sample size. |
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| کلیدواژه‌های انگلیسی مقاله |
Spontaneous abortion, thrombophilia, polymorphism, fetus |
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| نویسندگان مقاله |
sinem yalcintepe | sinem yalcintepe
department of medical genetics, faculty of medicine, canakkale onsekiz mart university, canakkale, turkey.
ozturk ozdemir | ozturk ozdemir
department of medical genetics, faculty of medicine, canakkale onsekiz mart university, canakkale, turkey.
servet ozden hacivelioglu | servet ozden hacivelioglu
department of gynecology and obstetrics, school of medicine, canakkale onsekiz mart university, canakkale, turkey.
cisem akurut | cisem akurut
department of medical genetics, faculty of medicine, canakkale onsekiz mart university, canakkale, turkey.
evrim koc | evrim koc
department of gynecology and obstetrics, school of medicine, canakkale onsekiz mart university, canakkale, turkey.
آحمت uludag | ahmet uludag
department of medical genetics, faculty of medicine, canakkale onsekiz mart university, canakkale, turkey.
emine cosar | emine cosar
department of gynecology and obstetrics, school of medicine, canakkale onsekiz mart university, canakkale, turkey.
فاطمه silan | fatma silan
department of medical genetics, faculty of medicine, canakkale onsekiz mart university, canakkale, turkey.
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| نشانی اینترنتی |
http://www.ijmcmed.org/browse.php?a_code=A-10-380-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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