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International Journal of Molecular and Cellular Medicine، جلد ۴، شماره ۱، صفحات ۱-۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Rab11 in Disease Progression |
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| چکیده انگلیسی مقاله |
Membrane/ protein trafficking in the secretory/ biosynthetic and endocytic pathways is mediated by vesicles. Vesicle trafficking in eukaryotes is regulated by a class of small monomeric GTPases the Rab protein family. Rab proteins represent the largest branch of the Ras superfamily GTPases, and have been concerned in a variety of intracellular vesicle trafficking and different intracellular signalling pathways. Rab11 (a subfamily of the Ypt/ Rab gene family), an evolutionarily conserved ubiquitously expressed subfamily of Rab GTPases, has been implicated in regulating vesicular trafficking through the recycling of endosomes. Rabs have been grouped into different subfamilies based on the distinct unambiguous sequence motifs. Three members: Rab11a, Rab11b and Rab25 make up the Rab11 GTPase subfamily. In this review article, we describe an overview over Rab11 subfamily with a brief structural aspect and its roles in implicating different disease progression. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
tanmay bhuin | tanmay bhuin
cell and developmental biology unit, department of zoology, the university of burdwan, golapbag-713104, india.
jagat k روی | jagat k roy
cytogenetics laboratory, department of zoology, banaras hindu university, varanasi-221 005, india.
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| نشانی اینترنتی |
http://www.ijmcmed.org/browse.php?a_code=A-10-40-3&slc_lang=en&sid=en |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
3 |
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