|
|
International Journal of Molecular and Cellular Medicine، جلد ۳، شماره ۲، صفحات ۸۸-۹۴
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژههای فارسی مقاله |
|
|
| عنوان انگلیسی |
Fetal Vegf Genotype is More Important for Abortion Risk than Mother Genotype |
|
| چکیده انگلیسی مقاله |
Background VEGF gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. VEGF polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. To evaluate the association between VEGF A C405G, C460T, C936T and C2578A polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously aborted fetuses, their mothers and healthy control cases. Methods 23 spontaneously aborted fetal materials, 22 mothers who had these abortions and 86 healthy control cases included to this study. VEGF A C405G, C460T, C936T and C2578A polymorphisms are analysed by Real Time PCR technique after genomic DNA isolation from all samples. Results VEGF A +405GG genotype and +405G allele were higher in fetuses comparing both with mothers and healthy control group. VEGF A +936TT genotype and +936T allele were higher in fetuses comparing with mothers. VEGF A +460C/T polymorphism CT and TT genotypes were higher in fetuses comparing with mothers. Conclusions We ascertained that VEGF A +405C/G, +460C/T, and +936C/T polymorphisms are risk factors for spontaneous abortion in fetal genotypes comparing with their mothers and healthy control cases. |
|
| کلیدواژههای انگلیسی مقاله |
Spontaneous abortion, VEGF, Polymorphism, Fetus, SNP |
|
| نویسندگان مقاله |
sinem yalcintepe | sinem yalcintepe
canakkale-turkey
فاطمه silan | fatma silan
canakkale-turkey
servet hacivelioglu | servet hacivelioglu
canakkale-turkey
آحمت uludag | ahmet uludag
canakkale-turkey
emine cosar | emine cosar
canakkale-turkey
ozturk ozdemir | ozturk ozdemir
canakkale-turkey
|
|
| نشانی اینترنتی |
http://www.ijmcmed.org/browse.php?a_code=A-10-218-1&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
1 |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|