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International Journal of Molecular and Cellular Medicine، جلد ۲، شماره ۲، صفحات ۸۰-۸۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Homocysteine intracerebroventricular injection induces apoptosis in the Substantia Nigra cells and Parkinson like behavior in rat |
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| چکیده انگلیسی مقاله |
Parkinson's disease is a degenerative disorder of the central nervous system. The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. Homocysteine (Hcy) is a non-protein amino acid. It is a homologue of the amino acid cysteine. The elevated levels of homocysteine in plasma have been associated with a number of disease states. Hcy (2 µmol / µl) was injected intracerebroventricular (i.c.v) in rats, five days later, the locomotor activity was measured with open field apparatus, Also apoptosis was investigated in substantia nigra cells by immunohistochemical analysis. Hcy could decrease locomotor activities significantly in rats as well as it could induce apoptosis in substantia nigra cells. These results suggest that Hcy is a neurotoxic metabolite and may induce cell death in some nuclei in the brain. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
امین عطایی | amin ataie
cellular and molecular biology research center cmbrc , babol university of medical science, babol, iran.
رامین عطایی | ramin ataie
pharmaceutical sciences research center, department of pharmacology and toxicology mazandaran, university of medical sciences, sari, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
زهرا منصوری | zahra mansouri
neuroscience research center. shahid beheshti university of medical science, tehran, iran.
سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)
سید محسن آقاجانپور | seyed mohsen aghajanpour
cellular and molecular biology research center cmbrc , babol university of medical science, babol, iran.
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| نشانی اینترنتی |
http://www.ijmcmed.org/browse.php?a_code=A-10-79-2&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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