|
|
Caspian Journal of Pediatrics، جلد ۱، شماره ۱، صفحات ۵-۸
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Preventive Effect of Clofibrate on Neonatal Hyperbilirubinemia |
|
| چکیده انگلیسی مقاله |
Background: Neonatal jaundice is a common problem that can result in serious neurological side effect such as Kern icterus. Several drugs are used to prevent neonatal jaundice. The effect of clofibrate in the prevention of hyperbilirubi-nemia in healthy term neonates has not been paid attention to. This study aimed to evaluate the preventive effect of clofibrate on neonatal jaundice in term neonates. Methods: This clinical trial was conducted on 80 healthy newborns randomly divided in to cases and control groups. The case group received clofibrate (50 mg/kg of body weight) orally in the first hour after birth and after the first period of breastfeeding. Serum bilirubin levels were measured in cord blood and again at 24, 48 and 72 hours after birth in both groups and were compared. Babies with clear jaundice on the first day, direct neonatal jaundice>1 mg/dl, sick infants, and infants of mothers treated with phenobarbital and preterm infants weighing less than 2500 gr were excluded. Results: The mean bilirubin level in cord blood and its level at 24, 48 and 72 hours after birth in control groups were 1.99±0.46, 2.88±0.88, 5.94±1.15, 7.65±1.69, respectively and in the case group were 2.12±0.75, 2.89±0.95, 5.8±1.16, 7.18±1.57, respectively. Thus, the mean bilirubin in the case group is lower, but it was not statistically significant. Also, sex distribution, Rh-blood group incompatibility and G6PD deficiency in both groups showed no significant difference. Conclusions: Our results showed that prophylactic clofibrate application reduced neonatal hyperbilirubinemia, but wasn’t statistically significant. |
|
| کلیدواژه‌های انگلیسی مقاله |
Clofibrate, Neonatal, Jaundice, Prevention |
|
| نویسندگان مقاله |
یداله زاهدپاشا | yadollah zahed pasha
non-communicable pediatric diseases research center,
صدرالدین مهدی پور | sadroddin mahdipour
pediatrics growth disorders research center, 17 shahrivar pediatric hospital, school of medicine
موسی احمدپور کچو | mousa ahmadpour kacho
non-communicable pediatric diseases research center
علی بیژنی | ali bijani
social determinants of health research center
مریم طاهری | maryam taheri
nicu msc student
|
|
| نشانی اینترنتی |
http://www.caspianjp.ir/browse.php?a_code=A-10-27-1&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
کاربردی |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|