Caspian Journal of Internal Medicine، جلد ۱۰، شماره ۴، صفحات ۲-۰
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عنوان انگلیسی Resistance integrons. Mini review
چکیده انگلیسی مقاله Integrons represent genetic mechanisms that allow bacteria to adapt and evolve rapidly through the stockpiling. The genes are embedded in a specific genetic structure called gene cassette (a term that is lately changing to integron cassette) that typically carries one promoterless ORF together with a recombination site (attC). Additionally, an integron will usually contain one or more gene cassettes that have been incorporated into it. The gene cassettes may encode genes for antibiotic resistance. In recent years, they have had a crucial role in the acquisition, expression, and dissemination of antibiotic resistance genes. Therefore, the ongoing threats posed by integrons require an understanding of their origins and evolutionary history. This review examines the functions and activities of integrons. It shows how antibiotic use selected particular integrons from among the environmental pool, so that integrons carrying resistance genes are now present in the majority of Gram-negative pathogens. In closing, it examines the potential consequences of widespread pollution with the novel integrons in Iran and the world.
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نویسندگان مقاله | Fariba Akrami
Department of Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran


| Mahdi Rajabnia
Department of Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran


| Iman VazifeSirzari
. Department of Management, Faculty of Management, Ferdowsi University of Mashhad, Mashhad, Iran
نشانی اینترنتی http://caspjim.com/browse.php?a_code=A-10-1336-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Microbiology
نوع مقاله منتشر شده Review Article
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