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Caspian Journal of Internal Medicine، جلد ۱۱، شماره ۱، صفحات ۱-۱۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer |
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| چکیده انگلیسی مقاله |
Background: Some studies have investigated the effects of iron on breast carcinogenesis and reported different findings about the association between Fe and breast cancer risk. This study was conducted to estimate this effect using meta-analysis method. Methods: A total of 20 articles published between 1984 and 2017 worldwide were selected through searching PubMed, Scopus, Embase, Web of Science, and Cochrane Library. Keywords such Breast Cancer, Neoplasm, Trace elements, Iron, Breast tissue concentration, Plasma concentration, Scalp hair concentration, toenail concentration and their combination were used in the search. Results: The total number of participants was 4,110 individuals comprising 1,624 patients with breast cancer and 2,486 healthy subjects. Fe concentration was measured in the various subgroups in both case and control groups. There were significant correlations between Fe concentration and breast cancer in breast tissue subgroup (SMD: 0.67 [95% CI: 0.17 to 1.17; P=0.009]). Whereas, there was no meaningful difference in Fe status between women with and without breast cancer related to scalp hair and plasma subgroups; (SMD: -3.74 [95% CI: -7.58 to 0.10; P=0.056] and (SMD:-1.14[95% CI: -2.30 to 0.03; P=0.055], respectively. Conclusion: The present meta-analysis indicated a positive and straight association between iron concentrations and risk of breast cancer but because of high heterogeneity we recommend more accurate future studies |
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| کلیدواژه‌های انگلیسی مقاله |
Breast Cancer, trace elements, Iron, Meta-analysis. |
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| نویسندگان مقاله |
| Akram Sanagoo
Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran
| Faezeh Kiani
Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran
| Marzieh Saei Gharenaz
Students Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Fatemeh Sayehmiri
Student Research Committee, Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Fatemeh koohi
Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran
| Leila Jouybari
Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran
| Majid Dousti
Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-1275-1&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Oncology |
| نوع مقاله منتشر شده |
Review Article |
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