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Caspian Journal of Internal Medicine، جلد ۱۳، شماره ۲، صفحات ۴-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Can cytokines response play a role in the treatment of fatal leptospirosis? |
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| چکیده انگلیسی مقاله |
Background: The northern coastal regions of Iran are endemic for leptospirosis which may range from a subclinical illness to a progressively fatal disease. There has been growing evidence that inflammatory markers play a significant role in the severity and prognosis of leptospirosis. This study aimed to investigate inflammatory cytokines in patients with leptospirosis. Methods: This descriptive-analytical prospective study was performed in 75 patients over 18 years old who had a positive microscopic agglutination test (MAT) titer from January to June 2019. SPSS software Version 20 was used for statistical analysis and the significance level was considered as p< 0.05. Results: The patients' age enrolled in this study are from 21 to 75 years with a mean and standard deviation of 48.6 ± 14.0. The male to female ratio in our participants was 54/21. Fever was the most common symptoms in 66 (88.0%) patients, followed by myalgia in 62 (82.7%) cases. The level of interleukin 10 was significantly higher in severe illness (P=0.003) and fatal cases (p< 0.028) compared with recovered patients. The level of TNF-α level was also higher in the severe illness and Weil's syndrome compared with the mild kind (P=0.022). Conclusion: Our results showed that the levels of TNF-α and IL-10 significantly increased in severe leptospirosis. Also, IL-10 was significantly higher in fatal cases. The inhibition of IL-10 production might play an important role in decreasing the risk of fatal outcomes in leptospirosis. |
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| کلیدواژه‌های انگلیسی مقاله |
Leptospirosis, Inflammatory cytokine, treatment, outcome, IL10 |
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| نویسندگان مقاله |
| Mahmoud Sadeghi Zavare
Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol
| Ahmad Alikhani
Department of Infectious Diseases, Antimicrobial resistance research center and communicable disease institute, Mazandaran University of Medical Sciences, Sari, Iran
| Kimia Mahmoodi
| Leila Delavaryan
| Ebrahim Salehifar
Department of clinical Pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
| Ali Reza Rafiei
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-2136-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Infectious Diseases |
| نوع مقاله منتشر شده |
Original Article |
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