| چکیده انگلیسی مقاله |
Background: Due to persistent infections of human central nervous system (CNS), polyomaviruses have been identified as one of the risk factors for brain tumor development. Human BK virus is of significant interest due to its experimental neuro-oncogenic potential and the possible association with CNS neoplasms. However, the results of different studies are discrepant. In the present study, we aimed to investigate the prevalence of BK virus genome and quantify BK viral load in Iranian patients with primary and metastatic brain malignancies. Methods: To assess the prevalence of BK virus sequences, a total of 58 fresh brain tumors were examined by quantitative real-time PCR. The BK viral load was determined as viral copy number per cell. Results: Of the 58 brain tumor samples BK tumor antigen (TAg) sequences were detected in 26 (44.8%) of cases. In primary brain tumors, BK virus sequences were recognized more frequently in schwannomas (15.5%) and meningiomas (12.1%). The mean BK virus TAg copy number in positive cases was 0.20×10-3±0.27×10-3 (range 0.01×10-3- 0.8×10-3) copies per cell. Conclusion: Taken together, in the present study low copy numbers of BK virus TAg gene was detected in brain tumor cells, which can indicate that BK virus may contribute to tumor induction by indirect mechanisms or neuro-persistence of this virus without any pathological consequences. |
| نویسندگان مقاله |
| Saghar Saber Amoli
Department of Microbiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
| Arqavan Zebardast
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
| Hossein Keyvani
Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
| Yousef Yahyapour
Infectious Diseases & Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
| Seyed Mohammad Ghodsi
Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Mahmood Maniati
School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
| Farzin Sadeghi
Cellular & Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
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