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Caspian Journal of Internal Medicine، جلد ۱۲، شماره ۱، صفحات ۶۵-۶۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Class I integrons among multidrug resistant Enterobacter spp. isolates from hospitalized patients in Babol, North of Iran |
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| چکیده انگلیسی مقاله |
Background: Multidrug resistance (MDR) in Enterobacter spp. has created therapeutic challenges all over the world. The present study was conducted for evaluating the prevalence of class I integron, determining the gene cassettes and antimicrobial resistance profile of Enterobacter spp. isolates from clinical samples in Babol, North of Iran. Methods: During a 13-month period, 30 Enterobacter spp. isolates were collected from Ayatollah Rouhani Hospital, Babol, Iran. Various types of antimicrobial agents were used to determine the resistance pattern. Class I integron and associated gene cassettes were detected by PCR assay. Results: The resistance rates to AP, CPM, CTX, TM, NI, IMI, AK, CIP and GM antimicrobials were 100%, 93.3%, 33.3%, 33.3%, 30%, 20%, 20%, 20% and 13.3%, respectively. The distribution results of int genes showed that 63.3% of isolates carried the intI genes. Also, the prevalence of aadB, dfrA1, blaOXA30 and blaPSE1 genes were estimated at 36.6%%, 33.3%, 6.6% and 0%, respectively. Conclusion: Our results showed that class I integrons have a widespread distribution among the Enterobacter spp. isolates and have clinical relevance to MDR isolates. The results confirmed the necessity for uninterrupted monitoring to prevent distribution of multidrug resistance among Enterobacter spp. strains in Iran |
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| کلیدواژه‌های انگلیسی مقاله |
class I integron, enterobacter, multi drug resistance (MDR). |
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| نویسندگان مقاله |
| Elaheh Ghasemi
Department of Biotechnology, Islamic Azad University, Damghan, Iran
| Elaheh Ferdosi-Shahndashti
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
| Mehdi Rajabnia
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
| Parisa Sabbagh
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
| Amirhosein Maali
Student Research Committee, Pasteur Institute of Iran, Tehran, Iran
| Azadeh Ferdosi-Shahandashti
Department of Microbiology, School of Sciences, Islamic Azad University, Ayatollah Amoli Branch, Amol, Iran
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-1640-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Microbiology |
| نوع مقاله منتشر شده |
Original Article |
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