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Caspian Journal of Internal Medicine، جلد ۱۲، شماره Case Supplement، صفحات ۳۸۳-۳۸۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
diagnosis of an occult gastric adenocarcinoma by oral manifestations (acanthosis nigricans) : a case report |
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| چکیده انگلیسی مقاله |
Background: Acanthosis nigricans (AN) is a condition with an important characteristics of symmetrical areas of thickened skin with grayish brown Hyperpigmentation. The mucosa may show a papillomatous surface, with or without hyperpigmentation. Lips and sites at risk of trauma may be affected and palmoplantar might also be present. In some rare cases, acanthosis nigricans presents as a sign of internal neoplasia, mostly a gastrointestinal cancer, and is called malignant acanthosis nigricans (MAN). Case Presentation: In this study, a 55-year-old female Iranian patient with malignant acanthosis nigricans (MAN) is reported. She was seeking esthetic treatment for her oral and perioral regions. The peculiarity of this case is simultaneous skin manifestation consistent with MAN, "tripe palms,"(TP) , and Leser-Trélat (LT) sign and mucosal changes in the oral cavity such as papillomatosis and roughened surfaces of the lips, hard palate and buccal mucosa. These changes harbored gastric adenocarcinoma stage T3 N3, but the patient was asymptomatic except for pruritis. Conclusion: There is an urgent need to suspect a correlation between oral and skin changes and the possibility of an internal neoplasia, therefore it is of utmost importance to refer these patients for early diagnosis of the underlying disease. This would improve the prognosis and lessen the consequences to a great extent. |
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| کلیدواژه‌های انگلیسی مقاله |
Gastric adenocarcinoma , Acanthosis Nigricans, Oral manifestations |
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| نویسندگان مقاله |
| pegah Mosannen Mozafari
Department of Oral Medicine, School of Dentistry, Oral and maxillofacial Disease Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| Roham Salek
Cancer Research Centre Faculty of Medicine Mashhad University of Medical Sciences, Mashhad, Iran
| Ava Taghizadeh
Department of Oral Medicine, School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran
| Mohammad Javad Yazdanpanah
Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| Homan Mosannen Mozaffari
Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran
| Elham Esmaeili
Department of Oral Medicine, School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-1572-1&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Oncology |
| نوع مقاله منتشر شده |
case report |
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