Caspian Journal of Internal Medicine، جلد ۱۲، شماره Case Supplement، صفحات ۴۹۱-۴۹۴
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عنوان انگلیسی Pregnancy outcome in patients with neuromyelitis optica spectrum disorder treated with rituximab: A case-series study
چکیده انگلیسی مقاله Background: Neuromyelitis optica spectrum disorder (NMOSD) is a neuroinflammatory disorder with a tendency to affect the spinal cord and optic nerves. As NMOSDs have a predilection for women of reproductive age and adopt an aggressive course during pregnancy, appropriate treatment strategies before conception and during pregnancy should be well-considered. Case Presentation: In this report, the pregnancy outcome of eight pregnancies following rituximab treatment was assessed, which led to 50% live births with mean birth weight of 2777.50 (SD: 545.92) grams. Two patients had abortions due to doctor's recommendation.  One pregnancy led to intrauterine fetal death (IUFD) due to nuchal cord.  No spontaneous abortions were encountered. Two patients received rituximab during pregnancy. No major malformations or serious neonatal infections were encountered. Conclusion: Rituximab should be administered by caution in NMOSD patients who want to be pregnant and the probable adverse effects of the drug should be discussed by patients.
کلیدواژه‌های انگلیسی مقاله Neuromyelitis Optica Spectrum Disorder, Rituximab, pregnancy
نویسندگان مقاله | Maral Seyed Ahadi
Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Ali Sahraian
Multiple Sclerosis Research Center; Neuroscience institute; Tehran University of Medical Sciences; Tehran; Iran


| Vahid Shaygannejad
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Nassim Anjidani
Medical Department, Orchid Pharmed Company, Tehran, Iran


| Seyed Ehsan Mohammadiani Nejad
Department of Neurology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Nahid Beladi Moghadam
Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Hormoz Ayromlou
Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Iran


| Gholam Ali Yousefi Pour
Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran


| Sepideh Yazdanbakhsh
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran


| Mehrdad Jafari
Imam Khomeini Hospital complex, Tehran University of Medical Sciences, Tehran, Iran


| Abdorreza Naser Moghadasi
Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://caspjim.com/browse.php?a_code=A-10-646-9&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Neurology
نوع مقاله منتشر شده Case Series
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