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International Journal of Molecular and Cellular Medicine، جلد ۱۰، شماره ۳، صفحات ۱۶۳-۱۸۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Curcumin in Combination with Other Adjunct Therapies for Brain Tumor Treatment: Existing Knowledge and Blueprint for Future Research |
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| چکیده انگلیسی مقاله |
Malignant brain tumors proliferate aggressively and have a debilitating outcome. Surgery followed by chemo-radiotherapy has been the standard procedure of care since 2005 but issues of therapeutic toxicity and relapse still remain unaddressed. Repurposing of drugs to develop novel combinations that can augment existing treatment regimens for brain tumors is the need of the hour. Herein, we discuss studies documenting the use of curcumin as an adjuvant to conventional and alternative therapies for brain tumors. Comprehensive analysis of data suggests that curcumin together with available therapies can generate a synergistic action achieved through multiple molecular targeting, which results in simultaneous inhibition of tumor growth, and reduced treatment-induced toxicity as well as resistance. The review also highlights approaches to increase bioavailability and bioaccumulation of drugs when co-delivered with curcumin using nano-cargos. Despite substantial preclinical work on radio-chemo sensitizing effects of curcumin, to date, there is only a single clinical report on brain tumors. Based on available lab evidence, it is proposed that antibody-conjugated nano-curcumin in combination with sub-toxic doses of conventional or repurposed therapeutics should be designed and tested in clinical studies. This will increase tumor targeting, the bioavailability of the drug combination, reduce therapy resistance, and tumor recurrence through modulation of aberrant signaling cascades; thus improving clinical outcomes in brain malignancies. |
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| کلیدواژه‌های انگلیسی مقاله |
Glioblastoma, polyphenol, combination therapy, resistance, sensitization, synergistic |
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| نویسندگان مقاله |
| Kavita Peter
Department of Biotechnology, Barkatullah University, Bhopal, M.P, India.
| Santosh Kumar Kar
Nano Herb Research Lab, KIIT-TBI, Bhubaneshwar, Odisha, India.
| Ragini Gothalwal
Department of Biotechnology, Barkatullah University, Bhopal, M.P, India.
| Puneet Gandhi
Department of Research, Bhopal Memorial Hospital and Research Centre, Bhopal, M.P, India.
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| نشانی اینترنتی |
http://ijmcmed.org/browse.php?a_code=A-10-1419-3&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cancer |
| نوع مقاله منتشر شده |
Review |
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