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International Journal of Molecular and Cellular Medicine، جلد ۱۰، شماره ۳، صفحات ۱۸۱-۱۸۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review |
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| چکیده انگلیسی مقاله |
The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine-protein kinase that senses and combines various environmental signals to regulate the growth and homeostasis of human cells. This signaling pathway synchronizes many critical cellular processes and is involved in an increasing number of pathological conditions such as diabetes, cancer, obesity, and metabolic syndrome. Here, we review different complications of diabetes that are associated with mTOR complex 1 imbalance. We further discuss pharmacological approaches to treat diabetes complications linked to mTOR deregulation. |
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| کلیدواژه‌های انگلیسی مقاله |
Diabetes, complications, mTOR, mTOR complex 1, signaling |
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| نویسندگان مقاله |
| Amir Yarahmadi
Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
| Negar Azarpira
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
| Zohreh Mostafavi-Pour
Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
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| نشانی اینترنتی |
http://ijmcmed.org/browse.php?a_code=A-10-4234-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Clinical Biochemistry |
| نوع مقاله منتشر شده |
Mini-review |
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