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International Journal of Molecular and Cellular Medicine، جلد ۹، شماره ۴، صفحات ۳۰۷-۳۱۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
PD-1, TIM-3, and LAG-3 Expression in T Cells in a Patient with Recurrent Ossifying Fibroma: A Case Report |
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| چکیده انگلیسی مقاله |
Central ossifying fibroma is a benign, slow-growing tumor of mesenchymal origin with a predilection for the mandibular premolar and molar areas. The immunophenotype of T cells involved in the antitumor response against this benign tumor is unknown. In this case report, we described a case of a 48-year-old woman presenting with a very large recurrent ossifying fibroma in the mandible, which was successfully treated with hemimaxillectomy. In addition, we evaluated the expression of programmed cell death 1 receptor (PD-1), lymphocyte activation gene-3 (LAG-3), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), CD69 (activation inducer molecule) and CD25 (α chain of the high-affinity IL-2 receptor) in T cell populations from the tumor and peripheral blood of this uncommon lesion. The patient presented recurrent ossifying fibroma, and the tumor-infiltrating and peripheral blood T cells showed expression of PD-1, LAG-3, and TIM-3, suggesting an exhausted T cell response. |
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| کلیدواژه‌های انگلیسی مقاله |
Immune checkpoint proteins, ossifying fibroma, programmed cell death 1 receptor, T-lymphocytes |
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| نویسندگان مقاله |
| Alejandro García-Muñoz
Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, Mexico.
| Nayeli Goreti Nieto-Velázquez
Research División, Hospital Juárez de México, Mexico City, Mexico.
| Gabriela Damian-Morales
Research División, Hospital Juárez de México, Mexico City, Mexico.
| Carlos Liceaga-Escalera
Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, Mexico.
| Luis Alberto Montoya-Perez
Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, Mexico.
| Madeleine Cruz-Vélez
Maxillofacial Surgery Service, Hospital Juárez de México, Mexico City, Mexico.
| Pabel Antonio Gómez-Hernández
Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (FES-Iztacala UNAM), Estado de México, México.
| Cynthia Trejo-Iriarte
Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (FES-Iztacala UNAM), Estado de México, México.
| Rodolfo Pastelin-Palacios
Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, México.
| Mario Moreno-Eutimio
Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (FES-Iztacala UNAM), Estado de México, México.
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| نشانی اینترنتی |
http://ijmcmed.org/browse.php?a_code=A-10-2913-1&slc_lang=en&sid=1 |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cancer |
| نوع مقاله منتشر شده |
Case Report |
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