|
|
International Journal of Molecular and Cellular Medicine، جلد ۹، شماره ۳، صفحات ۱۹۸-۲۰۶
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Plasma Levels of miR-27a, miR-130b, and miR-301a in Polycystic Ovary Syndrome |
|
| چکیده انگلیسی مقاله |
Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder in women of reproductive age. There is adequate evidence that suggests several microRNAs (miRNAs) are of great importance for PCOS. It seems that dysregulated expression of miR-27a, miR-130b, and miR-301a are associated with PCOS. The aim of this study was to investigate whether plasma levels of these miRNAs are different between patients with PCOS and healthy controls. 53 women with a definite diagnosis of PCOS, and 53 healthy controls were enrolled. MiRNAs expression levels in plasma were evaluated by real-time PCR. The diagnostic values of each miRNA were calculated by the receiver operating characteristic (ROC) curve and areas under the curves (AUC). The main clinical characteristics were not significantly different between the two groups. The circulating plasma expression levels of miR-27a and miR-301a had a significant increase (P = 0.0008 and P < 0.0001, respectively) but miR-130b expression level decreased in the patient group (P < 0.0001). The AUC for miR-27a, miR-130b, and miR-301a were 0.71, 0.77, and 0.66, respectively. A positive exponential was observed for miR-27a and miR-301a in multiple logistic regression. Changes in the plasma expressions of the studied miRNAs are likely to be associated with PCOS phenotypes. MiR-27a has a potential to serve as a diagnostic biomarker of PCOS. |
|
| کلیدواژه‌های انگلیسی مقاله |
Polycystic ovary syndrome, plasma, miRNA-27a, miRNA-130b, miRNA-301a |
|
| نویسندگان مقاله |
| Zahra Pourteymour Fard Tabrizi
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
| Sepideh Miraj
Department of Obstetrics and Gynecology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
| Shahram Tahmasebian
School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
| Sorayya Ghasemi
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
|
|
| نشانی اینترنتی |
http://ijmcmed.org/browse.php?a_code=A-10-2492-2&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Biomarkers (diagnosis & treatment) |
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|