|
|
Caspian Journal of Internal Medicine، جلد ۱۳، شماره ۳، صفحات ۳-۰
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Effect of Cassia fistula L. aqueous extract in maternal reproductive outcome, some serum indices and fetal anomaly frequency in rat |
|
| چکیده انگلیسی مقاله |
Background: Cassia fistula was used traditionally as laxative in pregnant women. Nevertheless, its fetal and maternal effects in pregnancy have not been studied yet. Methods: Oral (Lethal Dose, 50%) LD50 was determined in mice. In addition, a control group, pregnant rats in other 5 experimental groups (n=12) received orally C. fistula aqueous extract (500, 1000 and 2000 mg/kg), tween80 (10%) and distilled water during pregnancy up to the delivery (21-23 days). Some serum indices were evaluated in maternal blood samples after delivery. Histopathologic and histomorphometric evaluations were performed on the selected slices of newborn rats. Results: Anthraquinone content of the aqueous extract was 0.34% w/w. Oral LD50 was obtained more than 5000mg/kg. No abortions and newborn anomalies were observed in groups. The height and weight of the offspring were significantly reduced by the administration of 500, and 2000 mg/kg of extract compared to control. There was no significant change in maternal blood urea and creatinine. Higher concentration (2000mg/kg) led to ALT elevation. ALS levels decreased dose-dependency in treatment groups comparing to control. Histopathological findings showed significant lung vascular congestion, and hypertrophy of heart in group tween80, and significant hepatic parenchymal inflammation in tween80 and 2000mg/kg and 1000mg/kg groups. In all tissues of all groups, malpighian body area and bowman's capsule space significantly increased compared to the control group. Conclusion: It seems C. fistula extract is safe in pregnancy. Because of confounding role of tween80 in histopathological finding, more research is necessary. |
|
| کلیدواژه‌های انگلیسی مقاله |
Laxatives, Pregnancy, Cassia, Herbal medicine, Teratogenesis, Persian Medicine |
|
| نویسندگان مقاله |
| Saeed Hakiminia
Student Research Committee, Babol University of Medical Sciences, Babol, Ira
| Zahra Esmaeeli
Student Research Committee, Babol University of Medical Science, Babol, Iran
| Ali Akbar Moghadamnia
Department of Pharmacology, Babol University of Medical Sciences, Babol, Iran
| Seyyed Gholam Ali Jorsaraei
Department of Anatomical Sciences, Babol University of Medical Sciences, Babol, Iran
| Farideh Feizi
Department of Anatomical Sciences, Babol University of Medical Sciences, Babol, Iran
| Sorayya Khafri
Department of Biostatistics, Faculty of Medicine, Babol University of Medical Sciences, Babol, IR Iran
| Zahra Memariani
Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Science, Babol, Iran
| Hoda Shirafkan
Health Research Institute, Babol University of Medical Sciences, Babol, Iran
| Seyyed Ali Mozaffarpur
Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
|
|
| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-698-2&slc_lang=en&sid=1 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Traditional Medicine |
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|