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Caspian Journal of Internal Medicine، جلد ۱۳، شماره ۴، صفحات ۱-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Soluble urokinase plasminogen activator receptor (suPAR) in the emergency department: An update |
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| چکیده انگلیسی مقاله |
Background: The biomarker soluble urokinase plasminogen activator receptor (suPAR) is an indicator of inflammation which is increased in a variety of chronic and acute disease states. Its most promising application in the emergency setting is to aid in the prognostic stratification of patients by identifying those at high risk of deterioration. This is a narrative review of studies evaluating the use of suPAR Methods: We conducted a Medline search for studies on the use of suPAR in patients acutely admitted to the emergency department. Results: 25 original studies were included in the review. suPAR as a marker of inflammation has been used alone or combined to other inflammatory biomarkers in the assessment of patients suffering from various acute and chronic diseases in an emergency setting. As it is non-specific, it may increase in infectious disease, malignancy or acute coronary syndromes among other conditions, but quantitative suPAR levels correlate with disease severity. It may be useful for the identification of high risk patients regardless of underlying pathology. Conclusion: As the ideal biomarker in the emergency setting has not been identified yet, suPAR may be a promising addition to the established biomarkers for the initial assessment of patients in this setting. Additional research is necessary to evaluate the usefulness of suPAR guided management algorithms. |
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| کلیدواژه‌های انگلیسی مقاله |
suPAR, Biomarker, Emergency Department, Mortaliti, Infection, Sepsis |
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| نویسندگان مقاله |
| Dimitrios Velissaris
Department of Internal Medicine, University Hospital of Patras, Patras, Greece
| Nicholas Zareifopoulos
Department of Internal Medicine, University Hospital of Patras, Patras, Greece
| Vasileios Karamouzos
Intensive Care Unit, University Hospital of Patras, Patras, Greece
| Charalampos Pierrakos
Department of Intensive Care, Brugmann University Hospital, Université Libre de Bruxelles, Brussels, Belgium
| Menelaos Karanikolas
Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-2156-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Internal |
| نوع مقاله منتشر شده |
Review Article |
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