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Caspian Journal of Internal Medicine، جلد ۱۴، شماره ۲، صفحات ۱۵۳-۱۶۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Diabetic neuropathy: Past, present, and future |
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| چکیده انگلیسی مقاله |
Background: A sedentary lifestyle and an unhealthy diet have considerably increased the incidence of diabetes mellitus worldwide in recent decades, which has generated a high rate of associated chronic complications. Methods: A narrative review was performed in MEDLINE, EMBASES and SciELO databases, including 162 articles. Results: Diabetic neuropathy (DN) is the most common of these complications, mainly producing two types of involvement: sensorimotor neuropathy, whose most common form is symmetric distal polyneuropathy, and autonomic neuropathies, affecting the cardiovascular, gastrointestinal, and urogenital system. Although hyperglycemia is the main metabolic alteration involved in its genesis, the presents of obesity, dyslipidemia, arterial hypertension, and smoking, play an additional role in its appearance. In the pathophysiology, three main phenomena stand out: oxidative stress, the formation of advanced glycosylation end-products, and microvasculature damage. Diagnosis is clinical, and it is recommended to use a 10 g monofilament and a 128 Hz tuning fork as screening tools. Glycemic control and non-pharmacological interventions constitute the mainstay of DN treatment, although there are currently investigations in antioxidant therapies, in addition to pain management. Conclusions: Diabetes mellitus causes damage to peripheral nerves, being the most common form of this, distal symmetric polyneuropathy. Control of glycemia and comorbidities contribute to prevent, postpone, and reduce its severity. Pharmacological interventions are intended to relieve pain. |
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| کلیدواژه‌های انگلیسی مقاله |
diabetic neuropathy, diabetes mellitus, complication, treatment, glycemic control, Hb A1c |
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| نویسندگان مقاله |
| Juan Quiroz-Aldave
Division of Medicine, Hospital de Apoyo Chepén, Chepén, Peru
| María Durand-Vásquez
Division of Family Medicine, Hospital de Apoyo Chepén, Chepén, Peru
| Elman Gamarra-Osorio
Division of Endocrinology, Hospital Víctor Lazarte Echegaray, Trujillo, Peru
| Jacsel Suárez-Rojas
Universidad Científica del Sur, Lima, Peru
| Pela Jantine Roseboom
Division of Emergency Medicine, Hospital Regional Docente de Trujillo, Trujillo, Peru
| Rosa Alcalá-Mendoza
Division of Physical Medicine and Rehabilitation, Hospital Víctor Lazarte Echegaray, Trujillo, Peru
| Julia Coronado-Arroyo
Division of Obstetrics and Gynecology, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru
| Francisca Zavaleta-Gutiérrez
Division of Neonatology, Hospital Belén de Trujillo, Trujillo, Peru
| Luis Concepción-Urteaga
School of Medicine, Universidad Nacional de Trujillo, Trujillo, Peru
| Marcio Concepción-Zavaleta
Division of Endocrinology, Hospital Jorge Voto Bernales, Lima, Peru
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-2794-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Endocrinology |
| نوع مقاله منتشر شده |
Review Article |
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