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Caspian Journal of Internal Medicine، جلد ۱۴، شماره ۳، صفحات ۱-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
A systematic review and meta-analysis of the relationship between advanced glycation end products ceceptor (RAGE) gene polymorphisms and the risk of inflammatory bowel disease |
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| چکیده انگلیسی مقاله |
Background: In the pathogenesis of inflammatory bowel disease (IBD), the advanced glycation end product receptor (RAGE) has been involved. IBD is classified into Chron's disease (CD) and ulcerative colitis (UC). The promoter gene of the RAGE gene was discovered to have had unique polymorphisms that increased its transcriptional activity. This study, therefore, used a systematic review and meta-analysis to examine the relationship between the RAGE gene polymorphism and the risk of IBD. Methods: Databases such as PubMed, Scopus, and Cochrane library were searched to identify the relationship between RAGE gene polymorphisms and IBD susceptibility. We identified three Single Nucleotide Polymorphism (SNPs) (RAGE-429T/C, 374T/A, and G82S). The data were analyzed by RevMan 5.4. Results: Four studies (932 cases/1366 controls) were included. The findings showed no relationship between RAGE –429T/C and –G82S polymorphisms and the risk of IBD in all genetic models significantly. TT genotype of RAGE –374T/A polymorphisms was related to increased CD risk (OR=1.37; 95%CI=1.04-1.81; P=0.02), while TA genotype was determined to be a protective factor (OR=0.75; 95%CI=0.57-0.99; P=0.04). In UC, A allele of RAGE -374T/A was related to increase risk (OR=1.26; 95%CI=1.04-1.53; P=0.02), while T allele was determined to decrease risk (OR=0.79; 95%CI= 0.65-0.96; P=0.02). Conclusions: Our findings demonstrated that TT genotype and A allele of RAGE -374T/A polymorphisms were related to CD and UC risks, respectively, while the TA genotype and T allele possibly had a protective effect. RAGE –429T/C and RAGE –G82S polymorphisms were not related to increased IBD risk. |
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| کلیدواژه‌های انگلیسی مقاله |
inflammatory bowel disease, advanced glycation end products receptor, genetic polymorphisms, meta-analysis, systematic review |
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| نویسندگان مقاله |
| Ratih Puspita Febrinasari
Department of Pharmacology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
| Indah Sagitaisna Putri
Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
| Bastomy Eka Rezkita
Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
| Steven Irving
Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
| Akhmad Azmiardi
School of Health Sciences Mamba'ul 'Ulum, Surakarta, Indonesia
| Rabbinu Rangga Pribadi
Division of Gastroenterology, Pancreatobiliary and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia
| Marcellus Simadibrata
Division of Gastroenterology, Pancreatobiliary and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia
| Yulia Sari
Department of Parasitology, Faculty of Medicine, Universitas Sebelas Maret, Indonesia
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-2702-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Gastroentrology |
| نوع مقاله منتشر شده |
Review Article |
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