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International Journal of Molecular and Cellular Medicine، جلد ۱۲، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Inflammatory Responses of Women with Polycystic Ovary Syndrome in Vitro Differ from Healthy Women |
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| چکیده انگلیسی مقاله |
Polycystic ovary syndrome (PCOS) is a low-grade inflammatory state with increased serum levels of TNFα. The present study has compared the inflammatory responses to breast cancer cell lines in women with PCOS with healthy women. Peripheral blood mononuclear cells (PBMCs) isolated from 50 women with PCOS and 50 healthy controls were cultured in the trans-well co-culture system. These cells were stimulated with two distinct breast cancer cell lines. The proliferation of PBMCs, CD3+CD8+T cell percentages, and tumor necrosis factor-alpha (TNFα) concentration were evaluated after 48 and 72 hours of incubation. TNFα concentration and the proliferation rate of PBMCs after 48 hours of incubation were significantly increased in the PCOS group. However, after 72 hours, TNFα secretion was significantly decreased in the PCOS group. The ability of PBMCs to produce TNFα decreased gradually in women with PCOS. When the effects of low-grade inflammation and endocrine conditions on the cells decrease, the inability of PBMCs to create an inflammatory response will be altered. |
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| کلیدواژه‌های انگلیسی مقاله |
Inflammatory response, polycystic ovary syndrome, TNFα, breast cancer |
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| نویسندگان مقاله |
| Fatemeh Rezayat
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Mehri Hajiaghayi
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Nazanin Ghasemi
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Mehrnaz Mesdaghi
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Fahimeh Ramezani Tehrani
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
| Nariman Mosaffa
Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
http://ijmcmed.org/browse.php?a_code=A-10-5374-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Molecular & Cellular Immunology |
| نوع مقاله منتشر شده |
Original Article |
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