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Caspian Journal of Internal Medicine، جلد ۱۴، شماره ۴، صفحات ۶۱۸-۶۲۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Efficacy of prokinetic agents in diabetic gastroparesis comparing symptomatology and scintigraphy – An open-label trial |
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| چکیده انگلیسی مقاله |
Background: It is pertinent to objectively assess the severity of diabetic gastroparesis and tailor treatment accordingly. The current study was planned to document gastroparesis by gastric emptying scintigraphy (GES) objectively and see the effect of medications and diet control on clinical and GES after four weeks. Methods: A prospective, open-label randomized trial was conducted in the Department of Internal Medicine at a tertiary care teaching hospital over twelve months. Type 2 diabetic patients aged 18-65 years diagnosed with a case of delayed gastric emptying by gastric scintigraphy were included. All baseline GSCI was recorded, and then they were allotted to 3 groups – Group-1 (Levosulpiride 25mg once daily), group-2 (Cinitapride 1mg thrice daily), and Group-3 (Waitlisted control) by block randomization and followed-up weekly till four weeks. After four weeks duration, if not improved clinically, then Group-3 on diet and diabetic control only, were randomized into Levosulpiride 25mg once daily (Group 1), and Cinitapride 1mg Thrice daily (Group 2) for the next four weeks. Results: Forty confirmed cases with diabetic gastroparesis documented by Gastroparesis Symptom Cardinal Index (GCSI) scoring and later by Scintigraphy (GES) were included in this study. However, there was no statistically significant difference between the Levosulpiride and Cinitapride groups when all symptoms were taken into account. Levosulpiride was significantly more effective than Cinitapride in improving individual symptoms like nausea, vomiting, stomach fullness, and early satiety. Conclusion: Levosulpiride is better than Cinitapride in improving the symptoms of diabetic gastroparesis but no significant effect on gastric scintigraphy. |
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| کلیدواژه‌های انگلیسی مقاله |
Cinitapride, Diabetes Mellitus, Gastroparesis, Gastric scintigraphy, Gastric Emptying, Levosulpiride. |
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| نویسندگان مقاله |
| Ravi Kant
All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
| Madhuri Pratti
Department of Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
| Meenakshi Khapre
All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
| Poonam Yadav
All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
| Vandana Dhingra
Department of Nuclear Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-2131-3&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
pharmacology |
| نوع مقاله منتشر شده |
Original Article |
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