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Caspian Journal of Internal Medicine، جلد ۱۵، شماره ۱، صفحات ۲-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Effects of Nebivolol therapy on hemodynamic parameters and lipid profile compared to other beta blockers in patients with essential hypertension: a systematic review and meta-analysis |
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| چکیده انگلیسی مقاله |
Background: Besides being commonly used to treat high blood pressure, beta blockers are a family of drugs that are primarily used to regulate irregular cardiac rhythms. Nebivolol is a third generation of beta blockers, which is highly cardioselective, about three times as selective as bisoprolol. In this study, we aimed to evaluate Nebivolol's effectiveness and safety in comparison to other beta blockers.
Methods: We searched the online databases PubMed, ScienceDirect, and Cochrane Library for relevant RCTs evaluating Nebivolol's effect on hypertension management. Relative risk (WRR) and weighted mean difference (WMD), with a 95% confidence interval (CI) were utilized to quantify the impact of nebivolol medication in the treatment of hypertension using a random effects model.
Results: Twelve RCTs are included in the study, the patient numbers in every attempt ranged from 42-273 and 1456 patients in all were included in this review. Nebivolol does not significantly reduce SBP, DBP and HR compared to other beta blockers (WMD −0.57 mmHg, 95% CI [−1.55;0.42 mmHg] p=0.12 ; WMD −0.27 mmHg, 95% CI [−1.36;0.82 mmHg] p=0.63 ; WMD 0.10 BPM, 95% CI [−4.11;1.31 BPM] p=0.96, respectively). Patients treated with Nebivolol has significantly lower LDL-C (WMD -8.88 mg/dL, 95% CI [−15.28; -2.48 mg/dL] p=0.007) and significantly higher HDL-C (WMD 2.30 mg/dL, 95% CI [0.75; 3.84 mg/dL] p=0.004.
Conclusions: According to this study's findings, nebivolol is well tolerated and decreases LDL-C. And higher HDL-C than other beta blocker agents. This review does not recommend nebivolol as first-line treatment in hypertension as Nebivolol does not significantly reduce blood pressure and HR of patients.
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| کلیدواژه‌های انگلیسی مقاله |
Nebivolol, beta blockers, hemodynamic, lipid profile, hypertension |
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| نویسندگان مقاله |
| I Made Fermi Wikananda
Faculty of Medicine, Udayana University, Denpasar, Indonesia
| I Gusti Ngurah Metta Nurcahya
Faculty of Medicine, Udayana University
| Putu Gede Pradipta Mahardika Wijaya
Faculty of Medicine, Udayana University, Denpasar, Indonesia
| I Gde Raka Widiana
Department of Internal Medicine Udayana University / Prof Dr IGNG Ngoerah Hospital Denpasar
| Dwijo Anargha Sindhughosa
Department of Internal Medicine Udayana University / Prof Dr IGNG Ngoerah Hospital Denpasar
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-3046-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Internal |
| نوع مقاله منتشر شده |
Original Article |
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