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Caspian Journal of Internal Medicine، جلد ۱۵، شماره ۲، صفحات ۲۰۲-۲۱۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Prognostic significance of ASXL1 mutations in acute myeloid leukemia: A systematic review and meta-analysis |
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| چکیده انگلیسی مقاله |
Background: Although genetic mutations in additional sex-combs-like 1 (ASXL1) are prevalent in acute myeloid leukemia (AML), their exact impact on the AML prognosis remains uncertain. Hence, the present article was carried out to explore the prognostic importance of ASXL1 mutations in AML.
Methods: We thoroughly searched electronic scientific databases to find eligible papers. Twenty-seven studies with an overall number of 8,953 participants were selected for the current systematic review. The hazard ratio (HR) and 95% confidence interval (CI) for overall survival (OS), event-free survival (EFS), and relapse-free survival (RFS) were extracted from all studies with multivariate or univariate analysis. Pooled HRs and p-values were also calculated as a part of our work.
Results: The pooled HR for OS in multivariable analysis indicated that ASXL1 significantly diminished survival in AML patients (pooled HR: 1.67; 95% CI: 1.342-2.091).
Conclusions: ASXL1 mutations may confer a poor prognosis in AML. Hence, they may be regarded as potential prognostic factors. However, more detailed studies with different ASXL1 mutations are suggested to shed light on this issue.
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| کلیدواژه‌های انگلیسی مقاله |
Acute myeloid leukemia, Prognosis, Additional sex comb-like 1, ASXL1, ASXL1 mutation. |
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| نویسندگان مقاله |
| Maryam Sheikhi
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| Mehrdad Rostami
Departments of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
| Gordon Ferns
Division of Medical Education, Brighton and Sussex Medical School, Brighton, United Kingdom
| Hossein Ayatollahi
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| Payam Siyadat
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
| Yasamin Ayatollahi
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| Zahra Khoshnegah
Department of Laboratory Hematology and Blood Banking, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-2544-2&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Hematology |
| نوع مقاله منتشر شده |
Review Article |
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