| چکیده انگلیسی مقاله |
Background: Colorectal cancer could be developed from adenomatous polyp. The study aimed to evaluate the diagnostic significance of stromal and epithelial CD10 (Neprilysin) expression in patients with colorectal adenocarcinoma and adenomatous polyps.
Methods: This cross-sectional study was conducted on 141 patients with colorectal adenocarcinoma and adenomatous polyps referred to Ayatollah Rouhani Hospital from March 2020 to March 2021. Differential diagnoses of colorectal adenocarcinoma and adenomatous polyps were made colonoscopically, and then samples were taken from the lesions. The pathologists confirmed the final diagnosis as colorectal adenocarcinoma, high-grade or low-grade adenomatous polyps. The stromal and epithelial CD10 expression was evaluated by immunohistochemistry. The data was analyzed by SPSS 22 software (p<0.05).
Results: Sixty-five (46.1%) of the cases were low-grade polyps that were included positive (4 cases; 6.20%) and negative (61 cases; 93.80%) CD10 expression (P=0.001), also 76 (53.9%) of them were either high-grade polyps (21 cases) or adenocarcinomas (21 cases). Also, epithelial CD10 expression was significantly higher in the well-differentiated adenocarcinoma (38 cases) group than moderate (13 cases) and poor (4 cases) groups (P =0.001). Moreover, the CD10 expression level in the adenomatous polyps (10 positive cases and 76 negative cases) was correlated with the degree of dysplasia (P = 0.001) and the presence of tumor invasion (8 positive cases and 133 negative cases) (P = 0.001).
Conclusion: The CD10 expression is associated with an increased degree of dysplasia and the presence of tumor invasion in patients with pre-neoplastic lesions and colorectal adenocarcinoma.
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| نویسندگان مقاله |
| Ghasem Dehini
Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
| Hossein Ghorbani
Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
| Soraya Khafri
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical. Sciences, Babol, Iran
| Javad Shokri Shirvani
Department of Gastroenterology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
| Akramossadat Hosseini
Department of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
| Sahar Sadr Mohararpur
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
| Tina Rouhi
Department of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
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