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Caspian Journal of Internal Medicine، جلد ۱۵، شماره ۳، صفحات ۳۷۰-۳۷۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Beyond the division of multiple sclerosis into different subgroups: The Concept of Connectomopathy |
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| چکیده انگلیسی مقاله |
Multiple Sclerosis (MS) pathophysiologically is a dynamic and progressive disease that involves all parts of central nervous system. This widespread involvement of the CNS has paved the way for proposing a new theory in MS in which MS is considered as a connectomopathy. Connectomopathy is a new concept describing the diseases in which not only the brain connectome is completely and extensively damaged, but the defective connectome itself can also become a breeding ground for the disease’s progression. Connectomopathy provides a dynamic picture of MS. Since each person’s connectome is unique to him/herself, so MS patients’ connectomopathy varies from one to another. This variety not only challenges the classification of MS into different phenotypes, but also emphasizes the need for providing a personalized approach for the treatment of these patients.
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| کلیدواژه‌های انگلیسی مقاله |
Multiple Sclerosis, Connectomopathy, MS phenotypes |
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| نویسندگان مقاله |
| Abdorreza Naser Moghadasi
Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran
| Nasim Rezaeimanesh
Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran
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| نشانی اینترنتی |
http://caspjim.com/browse.php?a_code=A-10-646-13&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Neurology |
| نوع مقاله منتشر شده |
Review Article |
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