| چکیده انگلیسی مقاله |
It has been well documented that preeclampsia (PE) has a common etiological background, but little is known about its linkage at the molecular level.Non- coding RNAs are critical posttranscriptional regulators ofgene expression. This study was performed to determine whether PEis associated with alterations in placental non-codingRNAs expression. MicroRNA(miR)-155-5p and long non-coding RNA (lnc)sONE expression, in placentas collected sequentially from 59 patients with PE and 40 normotensive pregnancies were measured using real-time PCR.The relationship between miR-155-5p and lncsONE expressions wasanalyzed statistically. miR-155-5p expression was increased(fold change=1.6, P=0.04), whilelncsONE expression was not significantly changed(fold change=1.1, P=0.68), in placentas from patients compared with control group.miR-155-5p was upregulated in placentas from patients with PEand may have influencedeNOS expression. These findings indicate that miRNA-155-5p may be involved in PE pathogenesis and could be a potential biomarker for this disease. |
| نویسندگان مقاله |
فایزه عزیزی | faezeh azizi
department of medical genetics, faculty of medicine, shahidbeheshtiuniversity of medical sciences,tehran, iran.
ثریا صالح گرگری | soraya saleh gargari
feto-maternal unit, shohadayetajrish hospital, shahidbeheshti, university of medical sciences, tehran, iran.
صدیقه اسدی شهمیرزادی | sedigheh asadi shahmirzadi
feto-maternal unit, mahdiyeh hospital, shahidbeheshti, university of medical sciences, tehran, iran.
فاطمه دودانگه | fatemeh dodange
feto-maternal unit, mahdiyeh hospital, shahidbeheshti, university of medical sciences, tehran, iran.
وحید امیری | vahid amiri
school of allied medical sciences,shahidbeheshti, university of medical sciences, tehran, iran.
رضا میرفخرایی | reza mirfakhraie
department of medical genetics, faculty of medicine, shahidbeheshtiuniversity of medical sciences,tehran, iran.
میرداوود عمرانی | mir davood omrani
department of medical genetics, faculty of medicine, shahidbeheshtiuniversity of medical sciences,tehran, iran.
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