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International Journal of Molecular and Cellular Medicine، جلد ۶، شماره ۲، صفحات ۱۲۱-۱۳۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Association between ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133), FTO (rs9939609) Gene Polymorphism and Type 2 Diabetes with Dyslipidemia |
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| چکیده انگلیسی مقاله |
Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133) and FTO (rs9939609) genetic polymorphism in T2DM with dyslipidemia. Totally, 559 subjects including 221 T2DM cases with dyslipidemia, 158 T2DM without dyslipidemia and 180 controls were enrolled. ACE genetic polymorphism was evaluated by polymerase chain reaction (PCR), while MTHFR, FABP2, FTO genetic polymorphisms were evaluated by PCR and restriction fragment length polymorphism (RFLP). Significant association of ACE and MTHFR genetic polymorphisms were found in both group of cases [T2DM with dyslipidemia (P< 0.001, and P=0.008, respectively) and T2DM without dyslipidemia (P=0.003, and P=0.010, respectively)] while FABP2 and FTO genetic polymorphisms were significantly associated with T2DM without dyslipidemia (P=0.038, and P= 0.019, respectively). This study concludes that ACE, FABP2, FTO and MTHFR genes are associated with T2DM. Additionally, it also seems that ACE and MTHFR genes might be further associated with the development of dyslipidemia in T2DM cases. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
سید tasleem رضا | syed tasleem raza
department of biochemistry, era’s lucknow medical college and hospital, lucknow, india.
shania عباس | shania abbas
department of biochemistry, era’s lucknow medical college and hospital, lucknow, india.
زیبا siddiqi | zeba siddiqi
department of medicine era’s lucknow medical college and hospital, lucknow, india.
فرزانه مهدی | farzana mahdi
department of biochemistry, era’s lucknow medical college and hospital, lucknow, india.
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| نشانی اینترنتی |
http://ijmcmed.org/browse.php?a_code=A-10-1111-1&slc_lang=en&sid=en |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/245/article-245-449385.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Genetics & Disease |
| نوع مقاله منتشر شده |
Original Article |
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