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Caspian Journal of Pediatrics، جلد ۲، شماره ۲، صفحات ۱۵۸-۱۶۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Relation between bone mineral density and serum ferritin levels in patients with thalassemia major |
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| چکیده انگلیسی مقاله |
Background: Thalassemia/haemoglobinopathy is a hereditary disease with increased erythropoiesis and expansion of the bone marrow cavity. Consequently, there is a reduction in trabecular bone tissue resulting in osteopenia/osteoporosis. The present study was performed to determine bone mineral density (BMD) in children and adolescents with major thalassemia and its correlation with serum ferritin level. Methods: Seventy children and adolescents with major thalassemia were divided into two groups, (each group with 35 patients). Patients with serum ferritin level more than 1500 ng/dl were defined as case group and those with serum ferritin level lower than 1500 ng/dl were defined as control group. Thyroid and parathyroid function tests were performed as well as calcium and phosphorus serum level were checked. Dual X-ray Absorptiometry (DXA) was the diagnostic test for osteoporosis. Only patients with transfusion-dependent thalassemia major were enrolled. Patients with delayed puberty, hypothyroidism or parathyroid dysfunction, renal failure, liver failure, growth hormone deficiency and also those who used Calcitriol were excluded from the research. Results: Results showed that the mean serum ferritin in patients who had femoral osteoporosis was higher from those with osteopenia and normal density in the femur. (p=0.001). In addition, the mean serum ferritin in patients with vertebral osteoporosis was higher than that in those with osteopenia and normal bone density in the vertebral bones, (p=0.002). There is a significant difference between serum ferritin in different bone densities. Conclusions: Bone density is a good indicator of bone status in patients with major thalassemia and we recommend measuring it annually. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
حسن محمودی نشلی | hassan mahmoodi nesheli
non-communicable pediatric diseases research center, health research institute, babol university of medical sciences, babol, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)
الهام farahanian | elham farahanian
student research committee, babol university of medical sciences, babol, ir iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)
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| نشانی اینترنتی |
http://caspianjp.ir/browse.php?a_code=A-10-43-3&slc_lang=en&sid=en |
| فایل مقاله |
دریافت فایل مقاله |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
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