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Caspian Journal of Internal Medicine، جلد ۷، شماره ۳، صفحات ۱۷۸-۱۸۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of soluble human leukocyte antigen-G in pripheral blood of pregnant women with gestational diabetes melitus |
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| چکیده انگلیسی مقاله |
Background: Research says that diabetes may develop in over 10% of non-diabetic pregnant women. Diabetes which generally occurs late in second trimester and third trimester of pregnancy, it is called gestational diabetes. Overweight or suffering from obesity before pregnancy is type 2 diabetes risk factor. In most cases, diabetic symptoms disappear after delivery. HLA-G has an important role both in mother and fetus tolerance during pregnancy, it may also be effective in the protection of pancreatic islet cells. In this study, concentration of these molecules in pregnant women with gestational diabetes in comparison with normal pregnant women was investigated. Methods: In this case-control study, we measured serum HLA-G levels in 24 pregnant women with gestational diabetes compared with 30 normal pregnant women using sandwich ELISA. Results: HLA-G levels were significantly low in pregnant women with gestational diabetes in contrast to normal pregnant women (P=0.001). Conclusion: In this study, we found that HLA-G levels were reduced in women with gestational diabetes compared with control group. Therefore, it is suggested that measurement of HLA-G in pregnant women can be considered as an indicator in prognosis of gestational diabetes. |
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| کلیدواژه‌های انگلیسی مقاله |
HLA-G, gestational diabetes, pregnancy |
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| نویسندگان مقاله |
سعیده سادات شبیری | saeide sadat shobeiri
department of immunology , immunogenetic research center, faculty of medicine, mazandaran university of medical sciences, sari, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
سعید عابدیان کناری | saeid abediankenari
department of immunology , immunogenetic research center, faculty of medicine, mazandaran university of medical sciences, sari, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
بهاره لشتوآقایی | bahareh lashtoo aghaee
department of microbiology, school of medicine, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
زهرا رحمانی | zahra rahmani
immunogenetics research center, mazandaran university of medical sciences, sari, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
بهاره اسماعیلی گرجی | bahareh esmaeili gorji
department of biology, qaemshahr branch, islamic azad university, qaemshahr, iran.
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
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| نشانی اینترنتی |
http://www.caspjim.com/browse.php?a_code=A-10-391-1&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Obstetrics & Gynicology |
| نوع مقاله منتشر شده |
Original Article |
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