Caspian Journal of Internal Medicine، جلد ۶، شماره ۴، صفحات ۲۰۹-۲۱۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Relationship between hepatitis B DNA Viral load in the liver and it's histology in patient with chronic hepatitis B
چکیده انگلیسی مقاله Background: Serial measurement of hepatitis B virus (HBV) DNA levels in the liver and its relation with liver damage and serum HBV DNA levels are guide to begin and/or end a treatment course. This study evaluated the relationship between liver hepatitis B DNA viral load with liver histology in patients with chronic hepatitis B (HBV). Methods: Thirty patients with chronic anti-Hbe positive hepatitis B, with liver enzymes &ge 2 times of the upper limit of normal and positive HBV DNA of any amount were entered in the study. They underwent percutaneous liver biopsy. Liver and serum viral load were determined using real time polymerase chain reaction (RT-PCR) method. Liver function tests and liver histology for all cases were recorded. The amount of viral load in the liver and histological grading and staging were recorded. Data were collected and analyzed. Results: The mean age of the patients was 32.8±10 years and 24 (80%) patients were males. Ten (33.3%) patients had HBV viral load levels less than 20000 IU/mL. There was a significant correlation between liver viral load levels with staging or grading of liver damage. Conclusion: The results of the present study showed a strong correlation between liver viral load and liver damage in patients with chronic hepatitis B.
کلیدواژه‌های انگلیسی مقاله Chronic hepatitis B, liver, viral load, serum
نویسندگان مقاله تهمینه بی آزار | tahmineh biazar
infectious disease and tropical medicine research center, babol university of medical sciences, babol, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

یوسف یحیی پور | yousef yahyapour
infectious disease and tropical medicine research center, babol university of medical sciences, babol, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

محمدرضا حسنجانی روشن | mohammad reza hasanjani roushan
infectious disease and tropical medicine research center, babol university of medical sciences, babol, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

رمضان رجب نیا | ramazan rajabnia
infectious disease and tropical medicine research center, babol university of medical sciences, babol, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

محمود صادقی | mahmoud sadegi
infectious disease and tropical medicine research center, babol university of medical sciences, babol, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

حسن | hasan
infectious disease and tropical medicine research center, babol university of medical sciences, babol, iran.


محمد رعنایی | mohammad ranaei
department of pathology babol university of medical sciences, babol, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

معصومه بیانی | masomeh bayani
infectious disease and tropical medicine research center, babol university of medical sciences, babol, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

نشانی اینترنتی http://www.caspjim.com/browse.php?a_code=A-10-130-1&slc_lang=en&sid=en
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Infectious Diseases
نوع مقاله منتشر شده Original Article
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