|
|
Caspian Journal of Internal Medicine، جلد ۴، شماره ۳، صفحات ۶۹۲-۶۹۷
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژههای فارسی مقاله |
|
|
| عنوان انگلیسی |
Evaluation of tissue doppler echocardiography and T2* magnetic resonance imaging in iron load of patients with thalassemia major |
|
| چکیده انگلیسی مقاله |
Background: Iron-mediated cardiomyopathy is the main complication of thalassemia major (TM) patients. Therefore, there is an important clinical need in the early diagnosis and risk stratification of patients. The aim of this study was to evaluate the efficacy of tissue doppler imaging (TDI) to study cardiac iron overload in patients with TM using T2* magnetic resonance (MR) as the gold-standard non-invasive diagnostic test. Methods: A total of 100 TM patients with the mean age of 19±7 years and 100 healthy controls 18.8±7 years were evaluated. Conventional echocardiography, TDI, and cardiac MRI T2* were performed in all subjects. TDI measures included myocardial systolic (Sm), early (Em) and late (Am) diastolic velocities at basal and middle segments of septal and lateral LV wall. The TM patients were also subgrouped according to those with iron load (T2* ? 20 ms) and those without (T2* > 20 ms), and also severe (T2* ? 10 ms) versus the non-severe (T2* ? 10 ms).Results: Using T2* cardiovascular MR, abnormal myocardial iron load (T2* ? 20 ms) was detected in 84% of the patients and among these, 50% (42/84) had severe (T2* ? 10 ms) iron load. The mean T2* was 11.6±8.6 ms (5–36.7). A negative linear correlation existed between transfusion period of patients and T2* levels (r = -0.53, p=0.02). The following TDI measures were lower in patients than in controls: basal septal Am (p< 0.05), mid-septal Em and Am (p< 0.05), basal lateral Am (p< 0.05), mid-lateral LV wall Sm (p< 0.05) and Am (p< 0.05).Conclusion: Tissue doppler imaging is helpful in predicting the presence of myocardial iron load in Thalassemia patients. Therefore, it can be used for screening of thalassemia major patients. |
|
| کلیدواژههای انگلیسی مقاله |
|
|
| نویسندگان مقاله |
مهرداد ساروی | mehrdad saravi
احمد تمدنی | ahmad tamadoni
رزیتا جلالیان | rozita jalalian
حسن محمودی نشلی | hasan mahmoodi nesheli
مصطفی حجتی | mosatafa hojati
سعید رمضانی | saeed ramezani
|
|
| نشانی اینترنتی |
http://www.caspjim.com/browse.php?a_code=A-10-62-145&slc_lang=en&sid=en |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Infectious Diseases |
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|