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Caspian Journal of Internal Medicine، جلد ۳، شماره ۳، صفحات ۴۷۳-۴۷۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Pseudo-cholinesterase polymorphism in Mazandaran province (North of Iran) |
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| چکیده انگلیسی مقاله |
Background: Pseudocholinesterase (PChE) polymorphism has been a subject of several pharmacogenetic studies worldwide. The patients with atypical homozygous genotype do not only have reduced serum cholinesterase activities but also their elimination rate for some pharmacologically potent drugs decrease drastically. This study was designed to evaluate the PChE polymorphism in Mazandaran province (northern Iran) for the first time. Methods: About 5 ml plasma samples were collected from 200 healthy volunteers who visited "Iran Blood Transfusion Organization" centers all across Mazandaran province for blood donation. The PChE activity in presence or absence of dibucain was measured and based on obtained dibucain number (DN) volunteers were categorized to normal homozygous (Eu,u), atypical heterozygous (Eu,a), and atypical homozygous (Ea,a). Results: The average (±SD) of the PChE activity among the blood donors was 9.14 ± 1.93 IU (ranging from 4.1 to 16.6 IU). Only 2 persons (1%) had DN between 60 to 70 (Eu,a) and no one was categorized in 20
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
ابراهیم ذبیحی | ebrahim zabihi
میثم شعبان زاده | meisam shabanzadeh
سینا شیبانی | sina arabsheibani
علی اکبر مقدم نیا | ali akbar moghadamnia
محمود برادران | mahmoud baradaran
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| نشانی اینترنتی |
http://www.caspjim.com/browse.php?a_code=A-10-62-99&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Infectious Diseases |
| نوع مقاله منتشر شده |
Original Article |
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