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Caspian Journal of Internal Medicine، جلد ۲، شماره ۲، صفحات ۲۱۳-۲۱۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Metabolic capacity of CYP2D6 within an Iranian population (Mazandaran Province) |
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| چکیده انگلیسی مقاله |
Background: CYP2D6 is polymorphically expressed enzyme that show marked interindividual and interethnic variation. Phenotyping of CYP2D6 provides valuable information about real-time activity of this important drug-metabolizing enzymes through the use of specific probe drugs. The aim of this study was to identify the CYP2D6 oxidation phenotype with dextromethorphan (DEX) as a probe drug in Mazandarani ethnic group among Iranian population. Methods: The study included 71 unrelated healthy volunteers. Dextromethorphan hydrobromide (30 mg) was given orally to healthy subjects and peripheral venous blood samples (10 ml) were taken at 3 hr post-dose. Dextromethorphan and the metabolite dextrorphan (DOR) were analyzed by the HPLC method. The log DEX/DOR metabolic ratio (MR) at 3 hr plasma sample was used as the index of CYP2D6 activity and a value of 0.3 was used as the antimode separating extensive metabolizers (EM) and poor metabolizers (PM) phenotypes. Results: A 560-fold interindividual variation in dextromethorphan MRs was observed in this study. Considering the antimode 0.3 in log scale, 7.04% (5/71) volunteers were identified as PMs.Conclusion: The result showed that the frequency of CYP2D6 PM phenotypes accounted for 7.04% of subjects in our samples. Despite these findings, we propose a further study in larger samples to provide a wider image and to get more valuable information upon pharmacogenetic basis for individual therapy and personalized medicine. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
شیران محمدرضا | shiran mohammad reza
فاطمه sarzare | fatemeh sarzare
فاطمه مرآت | fatemeh merat
ابراهیم صالحی فر | ebrahim salehifar
علی اکبر مقدم نیا | ali akbar moghadamnia
سید محمد باقر هاشمی سوته | seyed mohammad bagher hashemi soteh
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| نشانی اینترنتی |
http://www.caspjim.com/browse.php?a_code=A-10-62-45&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Infectious Diseases |
| نوع مقاله منتشر شده |
Original Article |
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