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Caspian Journal of Internal Medicine، جلد ۲، شماره ۱، صفحات ۱۸۹-۱۹۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Thyroid function in major thalassemia patients: Is it related to height and chelation therapy? |
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| چکیده انگلیسی مقاله |
Background: One of the most common endocrine problems in major beta-thalassemia is hypothyroidism (HT). The aim of this study was to evaluate thyroid function status in major beta-thalassemia patients older than 10 years old. Methods: This cross sectional study was carried out on thalassemia major patients registered on Thalassemia Center of Amirkola Children Hospital in Babol. A questionnaire was filled out by the patients to evaluate the demographic information, quality of their last transfusions and chelation therapy. Growth parameters were evaluated. We assessed serum T4, TSH, T3RU and FTI in all patients and those with hypothyroidism, anti-thyroglobulin and anti-thyroid proxidase antibodies were checked. Results: One hundred-thirty patients (56 males and 74 females) were enrolled in this study. The mean age was 20.95±7.8 years. Short stature was seen in 41(31.3%) patients. In 53(40.8%) patients, weight was under normal range. HT was found in 19 patients (14.6%) 2 primary overt HT, 3 secondary HT and 14 subclinical HT were detected. No patient with HT had significant serum level of anti-thyroid antibodies. Correlation between HT and serum ferritin level was not significant (p=0.584) but it was significant for HT and short statures (p=0.002), also regular transfusion and chelation therapy were correlated with ferritin level. Conclusion: High prevalence of HT among thalassemic patients signifies the importance of regular screening for evaluation of endocrine function in these patients especially when short stature is present. |
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| کلیدواژه‌های انگلیسی مقاله |
Major thalassemia, Hypothyroidism, Serum ferritin |
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| نویسندگان مقاله |
پیمان eshragi | peiman eshragi
احمد تمدنی | ahmad tamaddoni
خدیجه ظریفی | khadijeh zarifi
امیر محمدحسنی | amir mohammadhasani
مجید امین زاده | majid aminzadeh
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| نشانی اینترنتی |
http://www.caspjim.com/browse.php?a_code=A-10-62-40&slc_lang=en&sid=en |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Infectious Diseases |
| نوع مقاله منتشر شده |
Original Article |
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